December 4, 2022

Vitamin C deficiency concerned with cognitive impairment among the many older hospitalized sufferers

Cognitive impairment amongst older hospitalized Australians may very well be the end result of decrease vitamin C levels, a Flinders Faculty-led analyze has found, paving the way in which for a potential therapy methodology.

Impression Credit score: Flinders College

Frequent in additional mature hospitalized sufferers, cognitive impairment may end up in a human being possessing points remembering gadgets, concentrating or producing selections.

“Earlier investigation has demonstrated that vitamin C performs a substantial place within the working of the mind, with scientific research buying that vitamin C deficiency might probably be linked with cognitive impairment, melancholy and confusion,” says direct writer Affiliate Professor Yogesh Sharma from Flinders College’s Faculty or college of Remedy and Basic public Wellness.

160 people aged in extra of 75 admitted to the Geriatric Analysis and Administration System on the Flinders Well being care Centre in Adelaide, the analysis group assessed their cognitive function and vitamin C quantities.

An entire of 91 folks (56.9%) have been discovered to have cognitive impairment, when 42 (26.3%) had been being discovered to be vitamin C poor with a level beneath 11 micromol/L, below which subject scurvy might produce.


Our outcomes confirmed that cognitive function scores have been noticeably lowered among the many people who ended up vitamin C poor, with additional examination suggesting vitamin C deficiency was practically 3 conditions way more possible to be related to cognitive impairment proper after adjustment for different components.”


Yogesh Sharma, Affiliate Professor, Flinders College’s Faculty or college of Drugs and Public Wellbeing


The assessment additionally discovered that the symptoms linked with scurvy have been very prone to be current among the many victims with or with out vitamin C deficiency. Fairly a number of of those indicators or signs of vitamin C deficiency are frequent in older people, who may need bleeding, bruising and pores and skin difficulties because of a quantity of different circumstances.

“It could effectively, thus, be difficult to diagnose vitamin C deficiency solely on attempting to find these distinct indicators in additional mature hospitalized people,” claims Affiliate Professor Sharma.

“Given we all know vitamin C deficiency is frequent among the many older hospitalized sufferers, skilled medical professionals have to proceed being vigilant for this affliction and validate a affected person’s vitamin C standing in suspected circumstances.”

The authors say although the analysis doesn’t present that vitamin C is a direct result in of the cognitive impairment, it has proven that vitamin C deficiency is widespread and is linked with cognitive impairment in additional mature hospitalized people.

“Additional scientific research can be required to make sure this hyperlink after which we are able to seem to create whether or not or not vitamin C substitute could also be useful in avoidance or reversal of the cognitive impairment,” claims co-author Professor Campbell Thompson from the College of Adelaide.


Journal reference:

Sharma, Y., et al. (2022) Marriage involving Vitamin C Deficiency and Cognitive Impairment in Older Hospitalised Purchasers: A Cross-Sectional Evaluation. Antioxidants.